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Free radicals are generated through several different pathways, e.g., during mitochondrial aerobic respiration, approximately 12% of electrons may escape the electron transport chain, and an estimated 2% of the oxygen consumed by mitochondria contributes to ROS formation, primarily the superoxide radical [25]

However, there are still many problems in upregulating the expression of glycolytic enzymes in osteoarthritic cartilage with drugs, and more precise targeted therapies need to be found from the perspective of biochemistry and clinical medicine

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Expression of an antitumoranalgesic peptide from the venom of Chinese scorpion Buthus martensii Karsch in Escherichia coli

We further describe how inflammatory and metabolic signals interact to amplify ferroptosis, creating a self-reinforcing cycle of tissue damage